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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Sophocarpine, Oxaliplatin
Phytochemical Name Sophocarpine (PubChem CID: 115269 )
Anticancer drug Name Oxaliplatin (PubChem CID: 9887053 )
Structure of
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Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 37
Ref_1
Pair Name Sophocarpine, Oxaliplatin
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Biological Phenomena Inhibition-->Epithelial-mesenchymal transition
Gene Regulation Up-regulation Expression CDH1 hsa999
Down-regulation Expression CDH2 hsa1000
Down-regulation Expression VIM hsa7431
In Vitro Model LoVo Colon adenocarcinoma Homo sapiens (Human) CVCL_0399
In Vivo Model Liver metastasis nude mouse models (n = 40) were prepared by the injection of LoVo cells suspended in PBS into the center point of the spleen using a 31-gauge needle.
Result Sophocarpine can enhance the inhibiting effect of oxaliplatin on colon cancer liver metastasis-in vitro and in vivo
03. Reference
No. Title Href
1 Sophocarpine can enhance the inhibiting effect of oxaliplatin on colon cancer liver metastasis-in vitro and in vivo. Naunyn Schmiedebergs Arch Pharmacol. 2021 Jun;394(6):1263-1274. doi: 10.1007/s00210-020-02032-8. Click
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